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Eck Lab - Structure and Mechanism in Cancer Signaling

Michael J. Eck, MD, PhD
STRUCTURE AND MECHANISM IN CANCER SIGNALING

Selected structures from the PDB (link will launch 3D viewer):
  • BRAF-MEK1-14-3-3 (PDB 6NYB)
  • EGFR in complex with osimertinib and allosteric inhibitor (PDB 7K1H)
  • Amino and carboxy terminal fragments of mDia1 (PDB 3O4X)
  • EGFR T790M Bound to WZ4002 (PDB 3IKA)
  • c-Src Kinase (PDB: 1FMK)
  • Focal adhesion kinase (PDB: 2J0K)
  • TANK-binding kinase 1 (PDB 4IM0)
  • Formin Homology-2 domain (PDB: 1UX4)​
  • Tumor necrosis factor-alpha (PDB: 1TNF)​​
  • Cbl complexed with ZAP-70 kinase (PDB: 2CBL)
  • Tyrosine phophatase SHP-2 (PDB: 2SHP)
  • ​EGFR in complex with Mig6 (PDB: 4R3P)
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